Lately, magic mushrooms have been gaining attention due to their potential usefulness in handling various mental illnesses, particularly depression. An emerging approach involves a regular intake of approximately 25 mg of the key ingredient, which can be procured from a mushroom dispensary. This dosage shows potential for providing relief and can complement conventional depression treatments.
A group of scholars have conducted research that indicates that psilocybin, the active compound in magic mushrooms, yields promising results in treating depression.
Key Points:
- Depression symptoms can improve in as little as eight days with psilocybin.
- The side effects of psilocybin are generally mild to moderate and are usually well-tolerated.
- A 25mg dose of psilocybin can cause perceptual changes, mood fluctuations, increased creativity, and a feeling of unity.

Only One Dose Required
A recent study employed a rigorous methodology, using a randomized, multi-blind design to compare a single dose of psilocybin to an active placebo (niacin). The study evaluated the onset, benefits’ duration, and safety of psilocybin over six weeks.
Study Participants
The study targeted individuals between 21 and 65 years who met the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria for Major Depressive Disorder (MDD) and were undergoing a depressive episode of at least 60 days.
Procedure of the Study
Each participant received a single 25-mg oral dose of psilocybin or a 100-mg dose of niacin. Niacin served as an active placebo, causing a sudden physiological response (flushing) designed to maintain the blinding integrity.
Both the psilocybin and the niacin placebo were given following a standard “set and setting” method. The preparatory sessions, facilitated by two professionals, lasted between 6 and The dosing session lasted between 7 and 10 hours, conducted in a relaxed environment. Four hours after the dosage, participants were urged to contemplate their experiences.
Insights Gained from the Study
Symptoms of depression began to decrease just eight days after psilocybin was administered. This promising effect was consistent throughout the six-week follow-up period. According to the Montgomery-Asberg Depression Rating Scale (MADRS), it showed higher response and remission rates compared to other psilocybin studies and Treatment-Resistant Depression.
Psilocybin outperformed niacin in terms of improving psychosocial functioning. The use of psilocybin proved beneficial in numerous areas, like reducing the overall severity of the disease, alleviating anxiety, self-reported depressive symptoms, and enhancing quality of life.
The majority of the subjects tolerated the compound well, experiencing only minor or moderate side effects, especially during the first dose. However, the psilocybin treatment had more frequent and severe side effects than niacin, which is consistent with our current understanding of its impacts.
Researchers noted that psychedelics such as psilocybin could cause side effects that standard rating scales may not always capture, or reveal previously unknown psychiatric disorders, even while effectively treating specific syndromes.
What Does a 25-mg Dose Mean?
A typical psychedelic dose is between 15 to 25 milligrams of psilocybin (1.5 to 2.5 grams of dried mushrooms). This is the usual dosage for those seeking a comprehensive psychedelic experience from magic mushrooms.
This dose can lead to changes in perception, mood alterations, increased creativity, and a feeling of unity with the environment. While slight visual effects may occur, intense hallucinations are rare. It’s akin to entering a lively dreamworld where reality blends seamlessly with a captivating mix of visual and auditory sensations.
Feelings of ecstasy often surface as dance, soft movements, or simply succumbing to the psychedelic rhythm. The experience usually lasts from 4 to 8 hours. At this level, visual distortions may become more pronounced. Patterns appear to move and morph, and the surroundings seem to pulsate with energy.
While this dosage can be controlled, it requires a regulated environment and a positive mindset. It offers a journey filled with amazement and discovery, inviting you to delve deeper into consciousness. with measured excitement.
- An enhanced perception of colors.
- Visual distortions, such as objects appearing to move or “breathe”.
- The phenomenon of synesthesia, like “seeing sounds” or “hearing colors”.
- Developing a deep appreciation for music.
- Spurts of laughter.
- Alterations in touch sensations.
- Indulging in introspection.
- Feeling euphoric.
- Distortions in the perception of time.
- An increased heart rate and blood pressure.
Product Selection at Magic Mushroom Shops
Magic mushroom stores stock a variety of products infused with psilocybin. Customers can choose from a wide range of options including dried mushrooms, edibles, capsules, and beverages. Dried mushrooms are particularly favored.
Health Canada recognizes over 200 species of magic mushrooms, with Psilocybe cubensis being a popular choice. This strain is offered in several varieties, providing a broad spectrum of choices for customers, similar to cannabis dispensaries.
Additional Shroom Products:
Edibles | Psilocybin-infused food items like gummies and chocolates. The dosage is made simple by indicating the amount per serving. |
Capsules | These tasteless capsules can be seamlessly added to your wellness routine. They contain only small amounts for a mild enhancement to your regimen. |
Beverages | These are akin to edibles, but in drinkable form. Versatile options include chocolate, coffee, or tea. |
Calculating Your Dosage at Magic Mushroom Dispensaries
Although magic mushrooms are not typically used to treat depression, Canada has taken a progressive step. They have approved the testing and medical utilization of psilocybin, a Schedule I substance under the Controlled Drugs and Substances Act, for certain patients suffering from severe major depressive disorder. This move could potentially benefit tens of thousands experiencing anxiety and depression as they investigate alternative solutions via clinical research.
Commonly Asked Questions
Can psilocybin be bought from a What exactly is a medicinal mushroom dispensary?
A medicinal mushroom dispensary usually carries products like Reishi, Turkey Tail, and Lion’s Mane. If you’re looking to delve into the mushroom universe, an online magic mushroom dispensary might be your best bet. These dispensaries offer a variety of mushroom products, including dried mushrooms and other psychedelic substances.
Is a 25 mg dosage appropriate for depression treatment?
Research into different psilocybin dosages for treating depression is still ongoing. Some studies have looked at smaller dosages, whereas others have examined higher amounts of psilocybin. One potential approach could be to begin with a microdose and gradually increase the dosage.
Is it feasible to buy shrooms in Toronto?
Online mushroom sellers offer the convenience of shopping from anywhere in Canada. Regardless of your province or city, these online platforms ensure delivery right to your doorstep.
What is the most economical product in an online mushroom shop?
Dried mushrooms are typically the first choice for customers due to the variety of quantities offered. The price can fluctuate depending on whether you require a small quantity like 1 gram or plan to purchase in larger volumes. While edibles and other products are priced reasonably, they might not be as budget-friendly as dried mushrooms.
Can a single dose of shrooms help alleviate depression?
Some studies indicate that a one-time use might be enough to lessen depression symptoms. However, it’s important to remember that study participants also engaged in talk therapy in addition to the treatment. The combination of psychedelic therapy and therapeutic conversation seems to yield the best results.
About the Author
This article was composed by Charles L. Raison and others; Jeremy D. Coplan, MD and Dorothy P. Reddy, MD; Albert Garcia-Romeu, Frederick S Barrett, Theresa M Carbonaro, Matthew W Johnson, and Roland R Griffiths; Vince Polito and Richard J. Stevenson; Rebecca Smausz, Joanna Neill, and John Gigg.
Affiliated Organizations:
- Usona Institute, located in Fitchburg, Wisconsin
- SUNY Downstate Medical Center, based in Brooklyn, New York
- Neurogenesis Clinics, situated in Brooklyn, New York
- The Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine, Baltimore, MD, USA
- The Center for Psychedelic and Consciousness Research at Johns Hopkins University School of Medicine, Baltimore, MD, USA
- The Department of Neuroscience at Johns Hopkins University School of Medicine, Baltimore, MD, USA
- The Department of Psychiatry and Behavioral Sciences at Johns Hopkins University School of Medicine, Baltimore, USA
- Department of Cognitive Science at Macquarie University, Sydney, Australia
- Department of Psychology at Macquarie University, Sydney, Australia
- The Division of Neuroscience and Experimental Psychology, Faculty of Biology, Medicine and Health at The University of Manchester, UK
- The Division of Pharmacy and Optometry, Faculty of Biology, Medicine and Health at The University of Manchester, UK
- Medical Psychedelics Working Group, under the umbrella of Drug Science, UK